I don’t think you can get the position of the ISS as lat/long only applies to the ground. These beacons are forwarded by the receiving station via RF. So you could extrapolate the general region of the world that the ISS is over at the time of the reception report.

However, APRS is much more than a positioning system. Again, look at the messages. You can parse them by eye most of the time and pull out messages. Search the past messages from me (NI2O-5) and you’ll see tests etc. That text could be anything. It could be telemetry data about battery health at the local radio tower or weather data or general 'hello world" stuff. Whatever you can fit into that space.

Take a look at http://aprs.fi where you’ll find a decent WWW GUI that’ll allow you access to all that APRS data as well as AIS (APRS for ships) data too.